基本信息
导师姓名：李玉芹
导师职称： 教授
电子邮箱： yuqinli2004@126.com
个人简介
李玉芹，博士，教授，博士/硕士生导师，湖南省青年骨干教师，湖南省食品科学技术协会常务理事，湖南省农林食品教指委委员，国家公派华盛顿州立大学访问学者，湘潭大学韶峰学者学术骨干。现为国家基金委化学部通讯评审专家、博士后科学基金通讯评审专家，湖南省自然科学基金评审专家，湖南省科技奖励评审专家，广西科技奖励评审专家，湘潭市科技专家，湘潭市工业新兴优势食品产业链专家。先后主持国家和省部级项目20余项。指导国家/省级大学生创新性实验计划项目3项，指导10余名研究生获得国家奖学金、湖南省优秀硕士论文、湘潭大学研究生校长特等奖等奖项。在Chem. Eng. J、Food Res. J、J. Agric. Food Chem、Bioresource Technol、Int J Biol Macromol、Algal Res、J Food Biochem、Curr Med Chem、Amino Acids、Mol Biotechnol、Pharmazie、Biotechnol Lett、World J Microb Biot等刊物发表论文50余篇，获中国授权发明专利13项，获湖南省高等教育省级教学成果三等奖1项（2022年）和湘潭大学教学成果奖一等奖1项（2022年）。
研究方向
1）藻菌基特色功能因子(EPA/DHA、活性肽、多糖、色素等）超高合成发酵调控、提取纯化、改性及应用；
2）藻菌基功能因子营养/健康构效关系；
3）藻菌基特色功能食品及功能性食品添加剂研发；
4）农副产品精深加工。
科研项目
1. 国家自然科学基金面上项目（2017-2020，21676228，微藻油脂合成积累路径关键酶基因的挖掘甄选及调控机制研究）
2. 国家自然科学基金青年项目（2014-2016，21306161，半连续稀释异养-贫营养两段法培育富油小球藻及调控机制）
3. 湖南省教育厅重点项目（2019-2021，18A068，微藻产油通路中相关基因的筛选鉴定及协同调控机制研究）
4. 湖南省自然科学基金面上项目（2021-2023，2021JJ30657，嗜酸碱衣藻共培养效应及其在强化胞内固碳产油过程中的功能解析）
5. 湖南省自然科学基金联合基金（2024-2026，2024JJ7548，共生微藻强化畜禽沼液氮磷转化及微藻富集调控机制研究）
6. 中国博士后基金面上项目（2012-2013，2012M521531，氮胁迫介导的小球藻油脂积累分子机理研究）
7. 中国博士后基金特别资助项目（2013-2014，2014T70775盐胁迫下耐盐小球藻及盐敏感小球藻油脂富集机制研究）
8. 湖南省教育厅优秀青年基金项目（2016-2019，16B254，微藻油脂合成积累路径关键调控酶基因挖掘甄选及其相关分子机制）
9. 湖南省自然科学基金青年基金（2017-2019，2017JJ3300，微藻脂质合成代谢关键调控酶的发掘及关联分子机制解析）
10. 湖南省自然科学基金面上项目（2014-2016，13JJ3062，化能异养-贫营养耦合培育富油脂小球藻及其分子机理）
11. 湖南省普通高校青年骨干教师培养对象经费（湖南省教育厅，2017-2019）
12. 湖南省工业和信息化技术创新项目（2013-2016，SQ2013ECD200067，基于乳酸菌的混合菌种发酵的鱼肉糜及其制备方法）
主要代表性成果
1. Li YQ*, Yuan ZQ, Chen D, Feng B. Proteomic analysis of lipid accumulation in Chlorella protothecoides cells by heterotrophic N deprivation coupling cultivation. Energy Fuels. 2013, 27: 4031-4040.
2. Li YQ*, Yuan ZQ, Chen D, Zeng HY, Feng B, Fang F. Potato feedstock as an organic carbon source for efficient biomass and lipid production by the heterotrophic microalga Chlorella protothecoides. Energy Fuels. 2013, 27: 3179-3185.
3. Li YQ*, Mu JX, Han FX, Xu H, Kong F, Xie F, Feng B. Production of biomass and lipid by the microalgae Chlorella protothecoides with heterotrophic-Cu (II) stressed (HCuS) coupling cultivation. Bioresour Technol. 2013, 148:283-292.
4. Li YQ*, Han FX, Xu H, Mu JX, Chen D, Feng B, Zeng HY. Potential lipid accumulation and growth characteristic of the green alga Chlorella with combination cultivation mode of nitrogen (N) and phosphorus (P). Bioresour Technol. 2014, 174:24-32.
5. Li YQ*, Xu H, Han FX, Mu JX, Chen D, Feng B. Regulation of lipid metabolism in the green microalga Chlorella protothecoides by heterotrophy-photoinduction cultivation regime. Bioresour Technol. 2015, 192: 781-791.
6. Mu JX, Li ST, Chen D, Xu H, Han FX, Feng B,Li YQ*. Enhanced biomass and oil production from sugarcane bagasse hydrolysate (SBH) by heterotrophic oleaginous microalga Chlorella protothecoides. Bioresour Technol. 2015, 185: 99-105.
7. Liu TT, Li YQ*, Liu F, Wang C. The enhanced lipid accumulation in oleaginous microalga by the potential continuous nitrogen-limitation (CNL) strategy. Bioresour Technol. 2016, 203:150-159.
8. Liu TT, Liu F, Wang C, Wang ZY, Li YQ*. The boosted biomass and lipid accumulation in Chlorella vulgaris by supplementation of synthetic phytohormone analogs. Bioresour Technol. 2017, 232:44-52.
9. Chao W, Wang ZY, Luo F,Li YQ*. The augmented lipid productivity in an emerging oleaginous model alga Coccomyxa subellipsoidea by nitrogen manipulation strategy. World J Microbiol Biotechnol, 2017, 33:160.
10. Liu TT, Luo F, Wang ZY, Li YQ*. The enhanced biomass and lipid accumulation in Coccomyxa subellipsoidea with an integrated treatment strategy initiated by brewery effluent and phytohormones. World Journal of Microbiology and Biotechnology, 2018, 34:25.
11. Wang ZY, Zhou R, Tang YF, Wang ZT, Feng B, Li YQ*. The growth and lutein accumulation in heterotrophic Chlorella protothecoides provoked by waste Monascus fermentation broth feeding. Applied Microbiology and Biotechnology, 2019, 103:8863-8874.
12. Wang ZY, Luo F, Wang ZT, Zhou R, Tang YF, Li YQ*. The potential growth and lipid accumulation in Coccomyxa subellipsoidea triggered by glucose combining with sodium acetate. World Journal of Microbiology and Biotechnology, 2019, 35:110.
13. Wang ZY, Hao LY, Ren Z, Lin SCK, Li YQ*. Metabolic profiling identified phosphatidylcholin as potential biomarker in boosting lipid accumulation in multiple microalgae. Biochemical Engineering Journal, 2021, 174:108130.
14. Li YQ*, Qi ZH, Fan YW, Tang YF, Zhou R. The concurrent production of lipid and lutein in Chlorella vulgaris triggered by light coupling nitrogen tactics. Biochemical Engineering Journal, 2022, 182:108435.
15. Li YQ*, Qi ZH, Fan YW, Zhou R, Tang YF. Boosting concurrent lipid accumulation and secretion by Cocccomyxa subellipsoidea with glucose coupling glycerol as accelerator. Algal Research, 2022, 67:102838.
16. Bai YN, Li YQ*, Tang YF, Zhou R, Fan YW. Rhizopus oryzae fermentation wastewater nutrient removal coupling protein fodder production by employing Chlorella pyrenoidosa. Bioresource Technology, 2022, 362:127858.
17. Zhou R, Qian Y, Lei ZY, Tang YF, Li YQ*. Production and characterization of exopolysaccharides from salinity-induced Auxenochlorella protothecoides and the analysis of anti-inflammatory activity. International Journal of Biological Macromolecules, 2023, 240: 124217.
18. Li YQ*, Luo YY, Wang ZY, Zou S, Meng X, Liu X. Enhancement of carbon bio-fixation and lipid accumulation in Coccomyxa subellipsoidea with triethanolamine CO2 absorbent manipulation. Biochemical Engineering Journal, 2023, 198: 109018.
19. Tang YF, Yan Y, Li YY, Yang YX, Li YQ*, Zhou R, Peng YZ. Paracetamol biodegradation coupling lipid biosynthesis in acclimated microalgae Coccomyxa subellipsoidea. Biochemical Engineering Journal, 2023, 200: 109308.
20. Li YQ, Meng X, Wang ZY, Lin X, Xu Y, Mou JH, Zhou R, Tang YF, Lin CSK, Li X. Utilization of tofu wastewater and Nannochloropsis oceanica for eutrophication mitigation and eicosapentaenoic acid valorization: Advancing carbon neutrality and resource recycling. Chemical Engineering Journal, 2024, 493: 152706
21. Li YQ*, Luo YY, Zhou R, Zuo XH, Zhang Y, Wang ZY, Li X, Zhang X, Qin ZH, Lin CSK. Coculture of Chlorella protothecoides and Coccomyxa subellipsoidea enhances cell growth and lipid accumulation: An effective strategy for biodiesel production. Chemical Engineering Journal, 2024, 486: 150302
22. Zhou R, Zhong L, Jia ST, Luo YY, Li YQ*, Tang YF. Preparation and characterization of aspirin–fucoidan complex and its admirable antitumor activity on human non-small cell lung cancer cells. International Journal of Biological Macromolecules, 2024, 263: 130163.
23. Tang YF, Liang F, Yan Y, Zeng YL, Li YQ*, Zhou R. Purification and identification of peptides from Hydrilla verticillata (Linn. f.) Royle with cytoprotective and antioxidative effect against H2O2-treated HepG2 cells. Journal of Agricultural and Food Chemistry, 2024, 72(8): 4170-4183.
24. Luo YY, Zhao SS, Fan ZX, Li YQ*, Peng ZF, Zhang YL, Feng SR, Mou JH, Wang ZY, Carol SKL, Li X. Sucrose non-fermenting 1-related protein kinase 2-14 participating in lipid elevating efficacy and biodiesel upgrade by Coccomyxa subllipsoidea. Chemical Engineering Journal, 2025, 505:159607.
25. Zhou R, Zuo WL, Xie YX, Wang YT, Li C, Tang YF, Wang ZY, Li YQ*. Sodium bisulfite boosted exopolysaccharide production by Auxenochlorella protothecoides: Potential mechanisms harnessing H2O2 signaling and carbon reallocation. Bioresource Technology, 2025, 420: 132121.
26. Peng ZF, Zhong L, Li YQ*, Feng SR, Mou JH, Miao YH, Lin CSK, Wang ZY, Li X. Harnessing oleaginous protist Schizochytrium for docosahexaenoic acid: Current technologies in sustainable production and food applications. Food Research International, 2025, 205:115996.
发明专利
1. 李玉芹，穆锦秀，陈迪等. 一种筛选微藻积脂调控酶的方法. 专利号: ZL 2014 1 0581886.3.
2. 李玉芹，王振瑶，周蓉等. 一种挖掘甄选微藻油脂合成代谢标志物的方法. 专利号：ZL 201811290739.5.
3. 李玉芹，雷铮宇，周蓉等. 一种具有抗氧化活性的小球藻胞外多糖. 专利号：ZL 201911155787.8.
4. 李玉芹，雷铮宇，周蓉等. 一种具有免疫调节活性的小球藻胞外多糖复合物及其制备方法和应用. 专利号：ZL 201911155767.0.
5. 李玉芹，钱娅，贾淑婷等. 一种改性岩藻多糖化合物及其制备方法和应用. 专利号：ZL 202211525744.6.
6. 李玉芹，尹帅，齐振华等. 一种共培养微藻提高α-亚麻酸油脂产率的方法. 专利号：202211216800.8.
7. 李玉芹，任站，贾权威等. 一种利用碳酸氢盐强化微藻固碳路径提高积脂效率的方法. 专利号：202211277914.3.
8. 李玉芹，任站，胡雅婷等. 一种胶球藻基因及其在调控生长和脂质合成中的应用. 专利号：202211321173.4.
